|
KMID : 0043319940170040236
|
|
Archives of Pharmacal Research
1994 Volume.17 No. 4 p.236 ~ p.239
|
|
|
Effects of Isoflavonoids on Mouse Lymphocyte Proliferation In Vitro
|
|
Namgoong Soon-Young
Lee Chang-Hee
Lim Hyun-Pyo
|
|
|
Abstract
|
|
|
|
The suppressive activity of isoflavonoids against lymphocyte proliferation in vitro was examined. Isoflabvonoid derivatives tested were isflavones isolated from Pueraia radix and synthesized 7-O-substituted biochanin A derivatives. The certain isoflavones such as biochanin A and 2-carbethoxybiochainin A were found to possess the suppressive activity against concanavaline A (Con A)-induced lymphocyte proliferation from mouse spleen. Against mixed lymphocyte culture reaction, biochanin A, 2-carbethoxybiochainin A, daidzein, formononetin, genistein and 7-O-isopropylbiochaninl A showed the suppressive activity at M. However, all isoflavones tested did not show the suppressive activity against lymphocyte proliferation induced by B-cell mitogen, lipopolysaccharide (LPS). In general, isoflavones were revealed to be less active than flavones/flavonols.
|
|
|
KEYWORD
|
|
|
Isoflavonoid, Lymphocyte proliferation, Structure-activity relationship, Pueraria radix, Biochanin A, Daidzien Genistein
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|
|